Among many problems that lead to infertility, endocrine dysfunction is one of the major ones. Also, recurrent pregnancy loss has been attributed to one of the endocrine dysfunctions in 10-25% cases. In women, fertility is well-regulated by hypothalamo-pituitary-ovarian axis. And the dysfunctions of thyroid, pancreas, adrenal glands, and pituitary gland disturb the normal HPO axis, resulting in pregnancy loss or infertility.
Following are the major endocrine disorders resulting in infertility:
(1) Hyper or hypo-thyroidism: moderate hyperthyroidism results in oligomenorrhea or amenorrhea and metrorrhagia. Severe cases lead to dysfunctions in LH and FSH, loss of midcycle LH peak, thus leading to anovulation and infertility. Also the risk of fetal growth retardation, intrauterine death, and pre-eclampsia are increased due to hyperthyroidism. Hypothyroidism usually results in anovulatory cycles and low FSH and LH. Pregnancy is rare with overt hypothyroidism and is associated with premature abortions, still births, neurologic dysfunctions, etc.
(2) Acromagaly: it results in decreased libido in both sexes and menstrual irregularities in females. Impaired gonadotropin secretion results in ovarian dysfunction and infertility.
(3) Diabetes: mortality rates in perinatal period remain high for undiagnosed and untreated diabetic cases, though insulin administration and therapy significantly reduces the risk. Menstrual irregularities and ovarian problems are common in diabetic women. Pre-implantation embryo development and folloculogenesis is affected in women with untreated diabetes. The fetal growth restriction is also common in diabetic mothers.
(4) Addison’s disease: the adrenal insufficiency results in amenorrhea and auto-immune ovarian failure, thus leading to infertility.
Well, the major thing one must remember is that with any of the endocrine dysfunctions, you need to get treated as early as you can after careful assessment of condition by expert doctors. You definitely have chances of conception thereafter!
Written By: Palm Beach Fertility Center - 9291 Glades Road, Suite 202 - Boca Raton, Florida 33434 Call: (800) 953-BABY
Palm Beach Fertility Center offers fertility treatment and reproductive services to South Florida and international patients. We specialize in In Vitro Fertilization (IVF), ART Services, Gamete Intra-fallopian Transfer (GIFT), Zygote Intra-fallopian Transfer (Zift), Intracytoplasmic Sperm Injection (ICSI), Blastocyst Transfer, Assisted Hatching (AH), Pre-implantation Genetic Diagnosis (PGD), Embryo Freezing/Cryopreservation, Egg Donation, Donor Egg Program and Surrogacy.
Following are the major endocrine disorders resulting in infertility:
(1) Hyper or hypo-thyroidism: moderate hyperthyroidism results in oligomenorrhea or amenorrhea and metrorrhagia. Severe cases lead to dysfunctions in LH and FSH, loss of midcycle LH peak, thus leading to anovulation and infertility. Also the risk of fetal growth retardation, intrauterine death, and pre-eclampsia are increased due to hyperthyroidism. Hypothyroidism usually results in anovulatory cycles and low FSH and LH. Pregnancy is rare with overt hypothyroidism and is associated with premature abortions, still births, neurologic dysfunctions, etc.
(2) Acromagaly: it results in decreased libido in both sexes and menstrual irregularities in females. Impaired gonadotropin secretion results in ovarian dysfunction and infertility.
(3) Diabetes: mortality rates in perinatal period remain high for undiagnosed and untreated diabetic cases, though insulin administration and therapy significantly reduces the risk. Menstrual irregularities and ovarian problems are common in diabetic women. Pre-implantation embryo development and folloculogenesis is affected in women with untreated diabetes. The fetal growth restriction is also common in diabetic mothers.
(4) Addison’s disease: the adrenal insufficiency results in amenorrhea and auto-immune ovarian failure, thus leading to infertility.
Well, the major thing one must remember is that with any of the endocrine dysfunctions, you need to get treated as early as you can after careful assessment of condition by expert doctors. You definitely have chances of conception thereafter!
Written By: Palm Beach Fertility Center - 9291 Glades Road, Suite 202 - Boca Raton, Florida 33434 Call: (800) 953-BABY
Palm Beach Fertility Center offers fertility treatment and reproductive services to South Florida and international patients. We specialize in In Vitro Fertilization (IVF), ART Services, Gamete Intra-fallopian Transfer (GIFT), Zygote Intra-fallopian Transfer (Zift), Intracytoplasmic Sperm Injection (ICSI), Blastocyst Transfer, Assisted Hatching (AH), Pre-implantation Genetic Diagnosis (PGD), Embryo Freezing/Cryopreservation, Egg Donation, Donor Egg Program and Surrogacy.
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